Staff
Dr. Ilaria Gionfriddo, MSc, PhD
Assistant Professor, Researcher
,
As the responsible senior staff of the drug screening I coordinate the screening of chemical libraries to identify either new or old drugs, or combinations, that go beyond those conventionally used in AML treatment and that would act selectively against NPM1 mutant-bearing leukemic cells.
+39-075-5782450
ilaria.gionfriddo@unipg.it
Dr. Francesca Milano, MSc, PhD
Assistant Professor, Researcher
As the senior staff responsible for the CRISPR/Cas9-based screening task of the project, my role is to find new pathways/genes specifically essential in NPM1-mutated AML (‘synthetic-lethal’ with NPM1 mutated protein) and coordinate and perform the following in vitro and in vivo validation studies for finding synthetic lethal partners and develop new drugs.
+39-075-5782450
francesca.milano@unipg.it
Research assistants
Eng. Dr. Giulio Spinozzi, MSc, PhD
Postdoctoral researcher
My role in the ERC Project (ContraNPM1AML) is next-generation sequencing data processing and analyses. The main topics of my research activity are related to the computational biology field and the developing of efficient bioinformatics pipelines in the big data era.
+39-075-5782450
giulio.spinozzi@unipg.it
Consultants
Dr. Corinne Quadalti, MSc, PhD
I work on the genetic engineering of cell lines and primary cells to unveil the role of AML-related genes. The main focus of my research is to edit the nucleophosmin gene (NPM1) and the genes most frequently assocaited to it in the leukemogenesis process using the cutting edge CRISPR/Cas9 technology.
corinne.quadalti2@gmail.com
PhD Students
Dr. Luca Albicocco Giovinati, MSc
My PhD activity in the ContraNPM1AML project will be focused on establishment and characterization of new relevant preclinical cellular models of AML with NPM1 and cooperating mutations, and their employment in pharmacogenomic studies.
+39-075-5782450
luca.albicocco@studenti.unipg.it / lucaalbi94@libero.it
Other contributors
Dr. Marcella Sabino, MSc, PhD
Researcher
The goal of my project is to evaluate the effect of different drugs in NPM1-mutated AML patients. To this aim, I will exploit the great potential of NGS technologies, analysing gene mutations and whole transcriptome, in order to find out gene expression variation induced by novel and existing drugs
+39-075-5782450
marcella.sabino@libero.it
Dr. Sara Pierangeli, MSc, PhD
Researcher
The main goal of my work is to create cellular models by transfecting or infecting cell lines and primary cells with gene of interest , optimizing the functional expression of mutated onco-proteins most frequently associated with NPM1 mutation.The aim is to dissect and characterize their role in the leukemogenesis process.
+39-075-5782450
sara.pierangeli@unipg.it / sara7pierangeli@libero.it
Management staff
Dr. Marco Bazzoffia
Administrative Secretary of Department of Medicine
+390755858100
marco.bazzoffia@unipg.it
Dr. Laura Pinacoli
Administrative Consultant
Project Manager Assistant
+390755782379
laura.pinacoli@gmail.com
Prof. Roberto Cippitani
Ethics Advisor
+390755858046
roberto.cippitani@unipg.it
Past collaborators
Dr. Alessia Adorni
Dr. Alessio Ferrari, MSc, PhD
Dr. Roberta Ranieri, MSc
Dr. Valerio Ciaurro, MSc
Dr. Lorenzo Ledda
Dr. Federica Mezzasoma, MSc, PhD
Dr. Roberta Rossi, MSc, PhD
Dr. Sofia Pascolini
Dr. Nicole Santoro, MD
Her main role in the project was to perform all the NGS related activities from the nucleic acid extraction and library preparation to the execution of the sequencing in all the available instruments at our facility.