Senior Staff


Dr. Ilaria Gionfriddo, MSc, PhD

Assistant Professor, Researcher

As the responsible senior staff of the drug screening I coordinate the screening of chemical libraries to identify either new or old drugs, or combinations, that go beyond those conventionally used in AML treatment and that would act selectively against NPM1 mutant-bearing leukemic cells.



Dr. Francesca Milano, MSc, PhD

Assistant Professor, Researcher

As the senior staff responsible for the CRISPR/Cas9-based screening task of the project, my role is to find new pathways/genes specifically essential in NPM1-mutated AML (‘synthetic-lethal’ with NPM1 mutated protein) and coordinate and perform the following in vitro and in vivo validation studies for finding synthetic lethal partners and develop new drugs.


Research assistants


Eng. Dr. Giulio Spinozzi, MSc, PhD

Postdoctoral researcher

My role in the ERC Project (ContraNPM1AML) is next-generation sequencing data processing and analyses. The main topics of my research activity are related to the computational biology field and the developing of efficient bioinformatics pipelines in the big data era.




Dr. Corinne Quadalti, MSc, PhD

I work on the genetic engineering of cell lines and primary cells to unveil the role of AML-related genes. The main focus of my research is to edit the nucleophosmin gene (NPM1) and the genes most frequently assocaited to it in the leukemogenesis process using the cutting edge CRISPR/Cas9 technology.



PhD Students


Dr. Luca Albicocco Giovinati, MSc

My PhD activity in the ContraNPM1AML project will be focused on establishment and characterization of new relevant preclinical cellular models of AML with NPM1 and cooperating mutations, and their employment in pharmacogenomic studies.

+39-075-5782450 /

Other contributors


Dr. Marcella Sabino, MSc, PhD


The goal of my project is to evaluate the effect of different drugs in NPM1-mutated AML patients. To this aim, I will exploit the great potential of NGS technologies, analysing gene mutations and whole transcriptome, in order to find out gene expression variation induced by novel and existing drugs



Dr. Sara Pierangeli, MSc, PhD


The main goal of my work is to create cellular models by transfecting or infecting cell lines and primary cells with gene of interest , optimizing the functional expression of mutated onco-proteins most frequently associated with NPM1 mutation.The aim is to dissect and characterize their role in  the leukemogenesis process.

+39-075-5782450 /

Management staff


Dr. Marco Bazzoffia

Administrative Secretary of Department of Medicine



Dr. Laura Pinacoli

Administrative Consultant
Project Manager Assistant



Prof. Roberto Cippitani

Ethics Advisor


Past collaborators


Dr. Alessia Adorni


Dr. Alessio Ferrari, MSc, PhD


Dr. Roberta Ranieri, MSc


Dr. Valerio Ciaurro, MSc


Dr. Lorenzo Ledda


Dr. Federica Mezzasoma, MSc, PhD


Dr. Roberta Rossi, MSc, PhD


Dr. Sofia Pascolini


Dr. Nicole Santoro, MD

Her main role in the project was to perform all the NGS related activities from the nucleic acid extraction and library preparation to the execution of the sequencing in all the available instruments at our facility.